School of Medicine - Basic Medical ScienceBiochemistry I

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生化学1集合

DNA double-strand break (DSB) is one of the most serious threats for cells. Improper repair of DSBs leads to cell death or carcinogenesis. DSBs can be induced by exogenous stimuli such as ionizing radiation, and endogenous normal cellular processes such as DNA replication, meiosis and V(D)J recombination. Since we found 53BP1 as a tumor suppressor p53-binding protein in 1994, many laboratories, including ours, have shown that 53BP1 is involved in cellular responses to DSBs.
Goals in our research are:
1) clarifying molecular mechanisms for the cell-cycle checkpoints and repair of DSBs.
2) generating a novel method in radiation therapy for cancer stem cells.

Contact Information

TEL: 076-218-8109 +81-76-218-8109 / FAX: 076-286-4693 +81-76-286-4693 / Email: biochem1@kanazawa-med.ac.jp

Faculty

Professor and Chair

  • IWABUCHI Kuniyoshi 生化学Ⅰ-3岩淵

Assistant Professor

  • MATSUI Tadashi
  • SAKASAI Ryo
  • SUNATANI Yumi

Research Assistant

  • HASHIKWA Yuko

Secretary

  • TANIHARA Kiyomi

Research Achievements

Research Activities

  • Sakasai R and Iwabuchi K. The distinctive cellular responses to DNA strand breaks caused by a DNA topoisomerase I poison in conjunction with DNA replication and RNA transcription.
    Genes Genet. Syst. 2016, 90(4): 187-194.
  • Baek HJ, Lee YM, Kim TH, Kim JY, Park EJ, Iwabuchi K, Mishra L, Kim SS. Caspase-3/7-mediated cleavage of β2-spectrin is required for acetaminophen -induced liver damage. Int J Biol Sci. 2016, 12(2): 172-183.
  • Iimori M, Watanabe S, Kiyonari S, Matsuoka K, Sakasai R, Saeki H, Oki E, Kitao H, Maehara Y. Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome instability.
    Nat Commun. 2016, doi: 10.1038/ncomms11117.
  • Matsui Y, Sunatani Y, Hayashi N, Okino K, Okushi Y, Mukai K, Adachi H, Yamaya H, Iwabuchi K, Yokoyama H. DNA double-strand breaks induced intractable glomerular fibrosis in renal allografts.
    Clin Exp Nephrol. 2016, 20 (3): 479-488, doi: 10. 1007/s10157-015-1174-3.
  • Yoo JS, Takahasi K, Ng CS, Ouda R, Onomoto K, Yoneyama M, Lai JC, Lattmann S, Nagamine Y, Matsui T, Iwabuchi K, Kato H, Fujita T. DHX36 enhances RIG-I signaling by facilitating PKR-mediated antiviral stress granule formation.
    PLoS Pathog. 2014, 10(3): e1004012.

External Research Funding

  • Grants-in-aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan (15K12210). 2015-2017, Iwabuchi K.
  • Grants-in-aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan (15K00546). 2015-2017, Matsui T.
  • Grants-in-aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan (15K16127). 2015-2017, Sakasai R.
  • Grants-in-aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan (26740020). 2014-2016, Sunatani Y.
  • Grants-in-aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan (23310041). 2011-2013, Iwabuchi K.